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Would you like the chance to join an award winning global biotechnology Company who focus on development and commercialisation of innovative gene therapies to change lives? My client has a broad pipeline with one clinical trial ongoing and two more coming in 2019/20 which allows more opportunities to change lives of patients by providing directed gene therapy as a life-long and potentially curative treatment.
You will be given the freedom to execute research, such as planning, organising and performing various in vivo experiments to assess the efficacy of AAV constructs. Furthermore, you will be part of a multi diverse team performing immunological, molecular and cell biology techniques including splenocyte antigen recall, ELISAs, qPCR, enzyme activity assay and primary immune cell isolation and culture from a variety of sources. You will be a senior member in the lab providing mentorship and guidance to junior colleagues.
Have experience working on Small animals- Animal license holder (PIL). Must be able to perform tasks such as: animal handling, administration of test agents through ip, iv, sc, blood collection, necropsy
You will need strong desire and aptitude to take a co-lead role on current/future programs. While also, playing a key role in the laboratory, providing guidance to junior staff while ensure effective running of the laboratory.
Moreover, execute a broad range of assays, including flow cytometry and sorting, cell-based and immune function/response assays and reporter assays to support in vitro and in vivo model.
Will be required to complete routine analytical tests with RNA, DNA and protein samples to include q-PCR, Western blot, ELISA, enzyme activity assays. Furthermore, have experience in cell culture techniques (primary cultures and cell lines), cell co-culture system.
Have a key eye for detail to provide expert problem solving skills. Ensuring company protocols ate followed such recording details of experimental protocols and data in laboratory notebooks.
Analysis, interpretation and report experimental results in small team meetings and company-wide meetings. Compliance with inventory maintenance including non-clinical samples, plasmids, cells and vectors
A Scientist with BSc/PhD in a relevant biological discipline or equivalent level of professional qualifications with at least three years of Laboratory experience
Experience designing in vivo experiments to assess the efficacy of AAV constructs is desired.
Skilled in design, organization and execution of in vivo studies, collection and analysis of readouts and generation of timely reports.
Skilled in standard immunological, molecular and cell biology techniques including splenocyte antigen recall, ELISAs, qPCR, enzyme activity assay and primary immune cell isolation and culture from a variety of sources.
Ability to priorities work across multiple projects and respond effectively as priorities changes
Prior work with in vivo models of monogenetic/rare diseases is desired.
Prior knowledge on the execution of preclinical AAV studies using various in vivo model systems related to AAV gene therapy development to deliver high-value data and support all aspects of AAV-based gene therapy projects
Knowledge of the drug discovery process
If you are looking to share an ambition of excellence and you are looking for a high paced work environment, this could be perfect fit for you.